产品名称
LSM1 Rabbit Polyclonal Antibody
蛋白名称
U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
O15116
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15116/entry
Mouse Swissprot No.
Q8VC85
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VC85
免疫原
Synthesized peptide derived from human protein . at AA range: 50-130
特异性
LSM1 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
LSM1 homolog, mRNA degradation associated(LSM1) Homo sapiens This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011],
细胞定位
Cytoplasm . Cytoplasm, P-body .
功能
function:Binds specifically to the 3'-terminal U-tract of U6 snRNA.,similarity:Belongs to the snRNP Sm proteins family.,subunit:LSm subunits form a heteromer with a donut shape.,tissue specificity:Has elevated expression in pancreatic cancer and in several cancer-derived cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
