产品名称
KMO Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8564
Human Swissprot No.
O15229
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15229/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/98256
Mouse Swissprot No.
Q91WN4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91WN4
Rat Gene Link
https://www.uniprot.org/uniprot/59113
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88867
免疫原
Synthesized peptide derived from human KMO AA range: 413-463
特异性
This antibody detects endogenous levels of KMO at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011],
组织表达
Highest levels in placenta and liver. Detectable in kidney.
细胞定位
Mitochondrion outer membrane ; Multi-pass membrane protein .
功能
catalytic activity:L-kynurenine + NADPH + O(2) = 3-hydroxy-L-kynurenine + NADP(+) + H(2)O.,cofactor:FAD.,function:Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.,miscellaneous:Increased in neuroinflammatory conditions. Inhibitors are investigated as potential neuroprotective drugs since they lead to an increased level of kynurenic acid, a neuroprotective NMDA receptor agonist.,pathway:Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 1/3.,similarity:Belongs to the aromatic-ring hydroxylase family. KMO subfamily.,tissue specificity:Highest levels in placenta and liver. Detectable in kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
