产品名称
LKHA4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4048
Human Swissprot No.
P09960
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P09960/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16993
Mouse Swissprot No.
P24527
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P24527
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P30349
免疫原
Synthesized peptide derived from human LKHA4 AA range: 68-118
特异性
This antibody detects endogenous levels of LKHA4 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015],
组织表达
Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.
功能
catalytic activity:(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate.,cofactor:Binds 1 zinc ion per subunit.,function:Hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). The enzyme also has some peptidase activity.,pathway:Lipid metabolism; leukotriene B4 biosynthesis.,similarity:Belongs to the peptidase M1 family.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
