产品名称
GGPPS Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9453
Human Swissprot No.
O95749
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O95749/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14593
Mouse Swissprot No.
Q9WTN0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTN0
Rat Gene Link
https://www.uniprot.org/uniprot/291211
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6F596
免疫原
Synthesized peptide derived from human GGPPS AA range: 141-191
特异性
This antibody detects endogenous levels of GGPPS at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010],
组织表达
Abundantly expressed in testis. Found in other tissues to a lower extent.
功能
catalytic activity:Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.,catalytic activity:Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.,catalytic activity:Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.,function:Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.,pathway:Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1.,pathway:Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.,pathway:Isoprenoid biosynthesis; geranylgeranyl-PP biosynthesis; geranylgeranyl-PP from farnesyl-PP and isopentenyl-PP: step 1/1.,similarity:Belongs to the FPP/GGPP synthetase family.,subunit:Homooctamer.,tissue specificity:Abundantly expressed in testis. Found in other tissues to a lower extent.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
