产品名称
FAIM3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9214
Human Swissprot No.
O60667
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60667/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/69169
Mouse Swissprot No.
A1KXC4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A1KXC4
Rat Gene Link
https://www.uniprot.org/uniprot/548326
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5M871
免疫原
Synthesized peptide derived from human FAIM3 AA range: 123-173
特异性
This antibody detects endogenous levels of FAIM3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010],
组织表达
Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression detected in nonhematopoietic cell lines including Hep-G2, HEK293 and HeLa. Detected at high levels in chronic lymphocytic leukemia cells.
细胞定位
[Isoform 1]: Membrane ; Single-pass membrane protein .; [Isoform 3]: Secreted . Detected in the serum. .
功能
domain:The Ig-like domain is required for the anti-apoptotic ability.,function:May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.,induction:By T-cell activation.,miscellaneous:'Toso' is a Japanese liquor drunk on New Year's day to celebrate long life and eternal youth.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,tissue specificity:Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat cells, CemT4 cells, MolT-4 cells, HB11.19 cells, and Reh cells. No expression detected in nonhematopoietic cell lines, including HepG2 cells, 293 cells and Hela cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
