产品名称
CBY1 Rabbit Polyclonal Antibody
基因名称
CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/25776
Human Swissprot No.
Q9Y3M2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y3M2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/73739
Mouse Swissprot No.
Q9D1C2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D1C2
Rat Gene Link
https://www.uniprot.org/uniprot/246768
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K4I6
免疫原
Synthesized peptide derived from human CBY1 AA range: 71-121
特异性
This antibody detects endogenous levels of CBY1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.
细胞定位
Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Golgi apparatus. Golgi apparatus, trans-Golgi network .
功能
function:Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.,miscellaneous:Chibby is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.,similarity:Belongs to the chibby family.,subcellular location:Nuclear, in a punctate manner. Also found in the trans-Golgi.,subunit:Homodimer; interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin.,tissue specificity:Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
