产品名称
F8I2 Rabbit Polyclonal Antibody
基因名称
F8A1 F8A; F8A2 F8A; F8A3 F8A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/474383
Human Swissprot No.
P23610
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P23610/entry
Mouse Swissprot No.
Q00558
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q00558
免疫原
Synthesized peptide derived from human F8I2 AA range: 33-83
特异性
This antibody detects endogenous levels of F8I2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is contained entirely within intron 22 of the factor VIII gene; spans less than 2 kb, and is transcribed in the direction opposite of factor VIII. A portion of intron 22 (int22h), containing F8A, is repeated twice extragenically closer to the Xq telomere. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. [provided by RefSeq, Jul 2008],
组织表达
Produced abundantly in a wide variety of cell types.
细胞定位
Cytoplasm . Nucleus . Early endosome . Nucleus, nuclear body . Diffuse presence in the cytoplasm and accumulation in the nucleus (PubMed:16476778). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity). Colocalized with HTT in endosomes (PubMed:16476778). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity). .
功能
function:Not known. Possible housekeeping role.,tissue specificity:Produced abundantly in a wide variety of cell types.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
