产品名称
COTL1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23406
Human Swissprot No.
Q14019
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14019/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72042
Mouse Swissprot No.
Q9CQI6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQI6
Rat Gene Link
https://www.uniprot.org/uniprot/361422
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B0BNA5
免疫原
Synthesized peptide derived from human COTL1 AA range: 29-79
特异性
This antibody detects endogenous levels of COTL1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Nucleus .
功能
function:Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization.,similarity:Belongs to the actin-binding proteins ADF family. Coactosin subfamily.,similarity:Contains 1 ADF-H domain.,subunit:Interacts with 5-lipoxygenase (5LO) in a calcium-independent manner.,tissue specificity:Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
