产品名称
LTC4S Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4056
Human Swissprot No.
Q16873
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q16873/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/17001
Mouse Swissprot No.
Q60860
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60860
Rat Gene Link
https://www.uniprot.org/uniprot/114097
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q925U2
免疫原
Synthesized peptide derived from human LTC4S AA range: 29-79
特异性
This antibody detects endogenous levels of LTC4S at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008],
组织表达
Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.
细胞定位
Nucleus outer membrane ; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein. Nucleus membrane ; Multi-pass membrane protein.
功能
catalytic activity:Leukotriene C(4) = leukotriene A(4) + glutathione.,disease:Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.,function:Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer. Interacts with ALOX5AP and ALOX5.,tissue specificity:Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
