产品名称
K1C40 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/125115
Human Swissprot No.
Q6A162
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6A162/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/406221
Mouse Swissprot No.
Q6IFX3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6IFX3
Rat Gene Link
https://www.uniprot.org/uniprot/287679
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6IFW2
免疫原
Synthesized peptide derived from human K1C40 AA range: 143-193
特异性
This antibody detects endogenous levels of K1C40 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009],
组织表达
Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).
细胞定位
intermediate filament,
功能
developmental stage:During differentiation of the hair, it is one of the last keratins expressed.,function:May play a role in late hair differentiation.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins.,tissue specificity:Expressed in skin and scalp. Also very weakly expressed in tongue, breast, colon and small intestine. In the hair follicle, it is specifically present in the upper hair cuticle. Not present in the upper cortex (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
