产品名称
MYT1L Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/23040
Human Swissprot No.
Q9UL68
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UL68/entry
Mouse Swissprot No.
P97500
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P97500
Rat Gene Link
https://www.uniprot.org/uniprot/116668
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P70475
免疫原
Synthesized peptide derived from human MYT1L AA range: 595-645
特异性
This antibody detects endogenous levels of MYT1L at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the zinc finger superfamily of transcription factors. The encoded protein belongs to a novel class of cystein-cystein-histidine-cystein zinc finger proteins that function in the developing mammalian central nervous system. Forced expression of this gene in combination with the basic helix-loop-helix transcription factor NeuroD1 and the transcription factors POU class 3 homeobox 2 and achaete-scute family basic helix-loop-helix transcription factor 1 can convert fetal and postnatal human fibroblasts into induced neuronal cells, which are able to generate action potentials. Mutations in this gene have been associated with autosomal mental retardation-39 and autism spectrum disorder. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016],
细胞定位
Nucleus . Chromosome . Preferentially binds to DNA binding sites that are in an open chromatin configuration. .
功能
function:May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS.,similarity:Contains 6 C2HC-type zinc fingers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
