产品名称
GRHPR Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9380
Human Swissprot No.
Q9UBQ7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBQ7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/76238
Mouse Swissprot No.
Q91Z53
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Z53
免疫原
Synthesized peptide derived from human GRHPR AA range: 151-201
特异性
This antibody detects endogenous levels of GRHPR at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Most abundantly expressed in the liver.
细胞定位
cytoplasm,peroxisomal matrix,cytosol,extracellular exosome,
功能
catalytic activity:Glycolate + NADP(+) = glyoxylate + NADPH.,disease:Defects in GRHPR are the cause of hyperoxaluria primary type II (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.,function:Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities.,similarity:Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.,subunit:Monomer.,tissue specificity:Ubiquitous. Most abundantly expressed in the liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
