产品名称
DEN1B Rabbit Polyclonal Antibody
基因名称
DENND1B C1orf218 FAM31B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/163486
Human Swissprot No.
Q6P3S1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P3S1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/329260
Mouse Swissprot No.
Q3U1T9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U1T9
免疫原
Synthesized peptide derived from human DEN1B AA range: 325-375
特异性
This antibody detects endogenous levels of DEN1B at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010],
组织表达
Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells.
细胞定位
Cytoplasm, cytosol . Cytoplasmic vesicle, clathrin-coated vesicle .
功能
PTM:Isoform 5 is phosphorylated on Tyr-475 and Tyr-484.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
