产品名称
PTPRQ Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
Q9UMZ3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UMZ3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/237523
Mouse Swissprot No.
P0C5E4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P0C5E4
Rat Gene Link
https://www.uniprot.org/uniprot/360417
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88488
免疫原
Synthesized peptide derived from human PTPRQ AA range: 1729-1779
特异性
This antibody detects endogenous levels of PTPRQ at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This locus encodes a member of the type III receptor-like protein-tyrosine phosphatase family. The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation. Mutations at this locus have been linked to autosomal recessive deafness. [provided by RefSeq, Mar 2014],
组织表达
In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is unclear.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 18 fibronectin type-III domains.,tissue specificity:In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
