产品名称
PDE3A Rabbit Polyclonal Antibody
蛋白名称
cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q14432
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14432/entry
Mouse Swissprot No.
Q9Z0X4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z0X4
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62865
免疫原
Synthesized peptide derived from human protein . at AA range: 250-330
特异性
PDE3A Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
组织表达
Blood,Epithelium,Liver,Myocardium,Penis,Platelet,
细胞定位
Membrane ; Multi-pass membrane protein . Cytoplasm, cytosol .
信号通路
Purine metabolism;Insulin_Receptor;Progesterone-mediated oocyte maturation;
功能
catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Inhibited by cGMP.,function:Hydrolyzes both cyclic AMP (cAMP) and cyclic GMP (cGMP).,online information:PDE3 entry,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
