产品名称
PURA1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/122622
Human Swissprot No.
Q8N142
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8N142/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11565
Mouse Swissprot No.
P28650
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P28650
免疫原
Synthesized peptide derived from human PURA1 AA range: 14-64
特异性
This antibody detects endogenous levels of PURA1 at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
组织表达
Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.
功能
catalytic activity:GTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP.,cofactor:Binds 1 magnesium ion per subunit.,function:Plays an important role in the de novo pathway of purine nucleotide biosynthesis.,pathway:Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.,similarity:Belongs to the adenylosuccinate synthetase family.,subunit:Homodimer.,tissue specificity:Predominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
