产品名称
CAR16 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/114769
Human Swissprot No.
Q5EG05
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EG05/entry
免疫原
Synthesized peptide derived from human CAR16 AA range: 101-151
特异性
This antibody detects endogenous levels of CAR16 at Human
宿主
Polyclonal, Rabbit,IgG
组织表达
Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
功能
function:Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.,induction:Down-regulated in patients suffering of Huntington disease.,similarity:Contains 1 CARD domain.,subunit:Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2.,tissue specificity:Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.