产品名称
RIPK4 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Swissprot No.
P57078
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P57078/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72388
Mouse Swissprot No.
Q9ERK0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ERK0
免疫原
Synthesized peptide derived from human RIPK4 AA range: 280-330
特异性
This antibody detects endogenous levels of RIPK4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008],
组织表达
Expressed in hair follicles and skin.
细胞定位
Cytoplasm. Membrane ; Peripheral membrane protein .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Plays a role in NF-kappa B activation.,PTM:May be phosphorylated by MAP3K2 and MAP3K3.,PTM:Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-388 and Asp-426.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,similarity:Contains 10 ANK repeats.,subunit:Interacts with PRKCB (By similarity). Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
