产品名称
RN112 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/7732
Human Swissprot No.
Q9ULX5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ULX5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/22671
Mouse Swissprot No.
Q96DY5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q96DY5
Rat Gene Link
https://www.uniprot.org/uniprot/24916
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O70418
免疫原
Synthesized peptide derived from human RN112 AA range: 377-427
特异性
This antibody detects endogenous levels of RN112 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in brain (PubMed:10574464). Decreased expression in glioma brain tumors as compared to normal brains (at protein level) (PubMed:28684796).
细胞定位
Membrane ; Multi-pass membrane protein . Membrane ; Peripheral membrane protein . Cytoplasm . Nucleus . Nucleus, nuclear body . Nucleus, nucleoplasm . Endosome . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Cell junction, synapse, postsynaptic density . Perikaryon . Cell projection, neuron projection . Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas. .
功能
similarity:Contains 1 RING-type zinc finger.,tissue specificity:Predominantly expressed in brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
