产品名称
SL9A3 Rabbit Polyclonal Antibody
蛋白名称
Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) (Solute carrier family 9 member 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P48764
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P48764/entry
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P26433
免疫原
Synthesized peptide derived from human protein . at AA range: 490-570
特异性
SL9A3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016],
组织表达
Colon,Kidney cortex,
细胞定位
Apical cell membrane ; Multi-pass membrane protein . In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity). .
功能
caution:The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors.,function:Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.,PTM:Phosphorylated by PKA, which inhibits activity.,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,subcellular location:In intestinal epithelial cells, localizes to the ileal brush border.,subunit:Binds SLC9A3R1 and SLC9A3R2. Interacts with SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
