BD-PT6513

SNTA1 Rabbit Polyclonal Antibody

常规抗体

SNTA1 SNT1

SNTA1

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

6640

https://www.uniprot.org/uniprot/6640

Q13424

https://www.uniprot.org/uniprotkb/Q13424/entry

Q61234

https://www.uniprot.org/uniprotkb/Q61234

Synthesized peptide derived from human SNTA1 AA range: 289-339

This antibody detects endogenous levels of SNTA1 at Human/Mouse

WB 1:500-2000;IHC-p 1:50-300

56kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013],

High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.

Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Cell junction . Cytoplasm, cytoskeleton . In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. .

domain:The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.,domain:The PH 1 domain mediates the oligomerization in a calcium dependent manner, and the association with the phosphatidylinositol 4,5-biphosphate.,domain:The SU domain binds calmodulin in a calcium-dependent manner.,function:Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-biphosphate.,PTM:Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD.,similarity:Belongs to the syntrophin family.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 SU (syntrophin unique) domain.,similarity:Contains 2 PH domains.,subcellular location:In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.,subunit:Monomer and homodimer. Interacts with the other members of the syntrophin family SNTB1 and SNTB2; SGCG and SGCA of the dystrophin glycoprotein complex; NOS1; GRB2; the sodium channel proteins SCN4A and SCN5A; F-actin and calmodulin (By similarity). Interacts with dystrophin protein DMD and related proteins DTNA and UTRN and with MAPK12, TGFA and GA.,tissue specificity:High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.