BD-PT6512

CRBB3 Rabbit Polyclonal Antibody

常规抗体

CRYBB3 CRYB3

CRBB3

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1417

https://www.uniprot.org/uniprot/1417

P26998

https://www.uniprot.org/uniprotkb/P26998/entry

12962

https://www.uniprot.org/uniprot/12962

Q9JJU9

https://www.uniprot.org/uniprotkb/Q9JJU9

64349

https://www.uniprot.org/uniprot/64349

P02524

https://www.uniprot.org/uniprotkb/P02524

Synthesized peptide derived from human CRBB3 AA range: 110-160

This antibody detects endogenous levels of CRBB3 at Human/Mouse/Rat

WB 1：500-2000

23kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. Mutations in this gene result in cataract congenital nuclear autosomal recessive type 2. [provided by RefSeq, Feb 2013],

disease:Crystallins do not turn over as the lens ages, providing ample opportunity for post-translational modifications or oxidations. These modifications may change crystallin solubility properties and favor senile cataract.,disease:Defects in CRYBB3 are the cause of autosomal recessive congenital nuclear cataract 2 (CATCN2) [MIM:609741]. CATCN2 is a form of non-syndromic congenital cataract. Non-syndromic congenital cataracts vary markedly in severity and morphology, affecting the nuclear, cortical, polar, or subcapsular parts of the lens or, in severe cases, the entire lens, with a variety of types of opacity. They are one of the major causes of vision loss in children worldwide and are responsible for approximately one third of blindness in infants. Congenital cataracts can lead to permanent blindness by interfering with the sharp focus of light on the retina during critical developmental intervals.,domain:Has a two-domain beta-structure, folded into four very similar Greek key motifs.,function:Crystallins are the dominant structural components of the vertebrate eye lens.,mass spectrometry: PubMed:8999933,similarity:Belongs to the beta/gamma-crystallin family.,similarity:Contains 4 beta/gamma crystallin 'Greek key' domains.,subunit:Homo/heterodimer, or complexes of higher order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.