产品名称
PIGZ Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/80235
Human Swissprot No.
Q86VD9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q86VD9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/239827
Mouse Swissprot No.
Q8BTP0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BTP0
免疫原
Synthesized peptide derived from human PIGZ AA range: 251-301
特异性
This antibody detects endogenous levels of PIGZ at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed at low level, with highest level in brain and colon.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
caution:It is uncertain whether Met-1 or Met-32 is the initiator.,function:Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,similarity:Belongs to the glycosyltransferase 22 family. PIGZ subfamily.,tissue specificity:Widely expressed at low level, with highest level in brain and colon.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
