产品名称
EXTL2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2135
Human Swissprot No.
Q9UBQ6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UBQ6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/58193
Mouse Swissprot No.
Q9ES89
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ES89
免疫原
Synthesized peptide derived from human EXTL2 AA range: 141-191
特异性
This antibody detects endogenous levels of EXTL2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
细胞定位
Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed exostosin-like 2]: Secreted. A soluble form is found in the serum.
功能
catalytic activity:UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.,function:Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.,online information:Exostosin-like 2,online information:GlycoGene database,pathway:Glycan metabolism; heparan sulfate biosynthesis.,PTM:The soluble form derives from the membrane form by proteolytic processing.,similarity:Belongs to the glycosyltransferase 47 family.,subcellular location:A soluble form is found in the serum.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
