产品名称
IRF7 Rabbit Polyclonal Antibody
蛋白名称
Interferon regulatory factor 7 (IRF-7)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q92985
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q92985/entry
Mouse Swissprot No.
P70434
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P70434
免疫原
Synthesized peptide derived from human protein . at AA range: 410-490
特异性
IRF7 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008],
组织表达
Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
细胞定位
Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.
信号通路
Toll_Like;RIG-I-like receptor;Cytosolic DNA-sensing pathway;
功能
function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) in IFN promoters and in the Q promoter (Qp) of EBV nuclear antigen 1 (EBNA1). Functions as a molecular switch for antiviral activity. Activated by phosphorylation in response to infection. Activation leads to nuclear retention, DNA binding, and derepression of transactivation ability.,induction:By type I interferons.,PTM:In response to a viral infection, phosphorylated on the C-terminal serine cluster. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subcellular location:The phosphorylated and active form accumulates selectively in the nucleus.,subunit:Homodimer; phosphorylation-induced. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2.,tissue specificity:Expressed predominantly in spleen, thymus and peripheral blood leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
