产品名称
TALDO Rabbit Polyclonal Antibody
基因名称
TALDO1 TAL TALDO TALDOR
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6888
Human Swissprot No.
P37837
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P37837/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/21351
Mouse Swissprot No.
Q93092
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q93092
Rat Gene Link
https://www.uniprot.org/uniprot/83688
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EQS0
免疫原
Synthesized peptide derived from human TALDO AA range: 21-71
特异性
This antibody detects endogenous levels of TALDO at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008],
功能
catalytic activity:Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.,disease:Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency) [MIM:606003]. It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris.,function:Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.,pathway:Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.,similarity:Belongs to the transaldolase family.,similarity:Belongs to the transaldolase family. Type 1 subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
