产品名称
ATS6 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11174
Human Swissprot No.
Q9UKP5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UKP5/entry
免疫原
Synthesized peptide derived from human ATS6 AA range: 989-1039
特异性
This antibody detects endogenous levels of ATS6 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016],
组织表达
Expressed at low levels in placenta and barely detectable in a number of other tissues.
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
cofactor:Binds 1 zinc ion per subunit.,domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,induction:Isoform 1 and 2 expressions are up-regulated by TNF-alpha in retinal pigment epithelial cells.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 5 TSP type-1 domains.,tissue specificity:Expressed at low levels in placenta and barely detectable in a number of other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
