BD-PT6467

PDLI3 Rabbit Polyclonal Antibody

常规抗体

PDLIM3 ALP

PDLI3

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

27295

https://www.uniprot.org/uniprot/27295

Q53GG5

https://www.uniprot.org/uniprotkb/Q53GG5/entry

53318

https://www.uniprot.org/uniprot/53318

O70209

https://www.uniprot.org/uniprotkb/O70209

114108

https://www.uniprot.org/uniprot/114108

Q66HS7

https://www.uniprot.org/uniprotkb/Q66HS7

Synthesized peptide derived from human PDLI3 AA range: 251-301

This antibody detects endogenous levels of PDLI3 at Human/Mouse/Rat

WB 1:500-2000;IHC-p 1:50-300

40kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012],

Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.

Cytoplasm, myofibril, sarcomere, Z line . Localizes to myofiber Z-lines.

disease:Quantitative or qualitative alterations of expression have not been detected in facioscapulohumeral muscular dystrophy (FSHD).,function:May play a role in the organization of actin filament arrays within muscle cells.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Localizes to myofiber Z-lines.,subunit:Interacts with ACTN2.,tissue specificity:Isoform 1 is highly expressed in differentiated skeletal muscle. Isoform 2 is heart-specific.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.