产品名称
ADAT3 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/113179
Human Swissprot No.
Q96EY9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96EY9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/100113398
Mouse Swissprot No.
Q6PAT0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PAT0
Rat Gene Link
https://www.uniprot.org/uniprot/100125374
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q561R2
免疫原
Synthesized peptide derived from human ADAT3 AA range: 295-345
特异性
This antibody detects endogenous levels of ADAT3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016],
细胞定位
nucleoplasm,cytosol,
功能
caution:Val-225 is present instead of the conserved Glu which is an active site in the cytidine and deoxycytidylate deaminase family of enzymes. It is suggested that this protein may act as a regulatory subunit.,cofactor:Zinc.,function:May be involved in deamination of adenosine-34 to inosine in many tRNAs as a regulatory subunit .,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
