产品名称
BCL3 Rabbit Polyclonal Antibody
蛋白名称
B-cell lymphoma 3 protein (BCL-3) (Proto-oncogene BCL3)
反应种属
Human,Rat,Mouse,,Goat
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
P20749
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P20749/entry
Mouse Swissprot No.
Q9Z2F6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z2F6
免疫原
Synthesized peptide derived from human protein . at AA range: 340-420
特异性
BCL3 Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus. Cytoplasm . Cytoplasm, perinuclear region . Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. .
功能
disease:A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.,function:Could be a transcriptional activating factor. Functions as a form of I-kappa-B specific for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus.,PTM:Activated by phosphorylation.,similarity:Contains 7 ANK repeats.,subunit:Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2 and COPS5.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
