产品名称
AP2S1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1175
Human Swissprot No.
P53680
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P53680/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/232910
Mouse Swissprot No.
P62743
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P62743
Rat Gene Link
https://www.uniprot.org/uniprot/65046
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P62744
免疫原
Synthesized peptide derived from human AP2S1 AA range: 26-76
特异性
This antibody detects endogenous levels of AP2S1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
细胞定位
Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. .
功能
function:Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2S1/AP17 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides.,similarity:Belongs to the adaptor complexes small subunit family.,subcellular location:Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.,subunit:Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
