产品名称
FCGRN Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2217
Human Swissprot No.
P55899
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P55899/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14132
Mouse Swissprot No.
Q61559
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61559
Rat Gene Link
https://www.uniprot.org/uniprot/29558
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P13599
免疫原
Synthesized peptide derived from human FCGRN AA range: 146-196
特异性
This antibody detects endogenous levels of FCGRN at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
组织表达
Expressed in full-term placenta, heart, lung, liver, muscle, kidney, pancreas, and both fetal and adult small intestine.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Endosome membrane .
功能
function:Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.,similarity:Belongs to the immunoglobulin superfamily.,subunit:FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
