产品名称
SO1C1 Rabbit Polyclonal Antibody
基因名称
SLCO1C1 OATP14 OATP1C1 OATPF SLC21A14
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/53919
Human Swissprot No.
Q9NYB5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9NYB5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/58807
Mouse Swissprot No.
Q9ERB5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ERB5
Rat Gene Link
https://www.uniprot.org/uniprot/84511
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPZ7
免疫原
Synthesized peptide derived from human SO1C1 AA range: 634-684
特异性
This antibody detects endogenous levels of SO1C1 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009],
组织表达
Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum. Not strongly enriched in cerebral microvessels.
细胞定位
Cell membrane ; Multi-pass membrane protein . Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity). .
功能
function:Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency.,similarity:Belongs to the organo anion transporter (TC 2.A.60) family.,tissue specificity:Highly expressed in brain and in Leydig cells in testis. Detected in many brain regions with the exception of pons and cerebellum.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
