产品名称
CCHCR Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54535
Human Swissprot No.
Q8TD31
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TD31/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/240084
Mouse Swissprot No.
Q8K2I2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K2I2
免疫原
Synthesized peptide derived from human CCHCR AA range: 180-230
特异性
This antibody detects endogenous levels of CCHCR at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.
功能
function:May be a regulator of keratinocyte proliferation or differentiation.,polymorphism:HCR*WWCC is associated with susceptibility to psoriasis. Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is a multifactorial disease characterized by red, scaly skin lesions that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. The lesions are caused by hyperproliferative keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. The usual age of onset of psoriasis is between 15 and 30 years, although it can present at any age. Association of HCR with psoriasis seem to be due to linkage disequilibrium with CW*0602 (PubMed:11348465). HCR is unlikely to be directly involved in psoriasis development.,tissue specificity:Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
