产品名称
STX8 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9482
Human Swissprot No.
Q9UNK0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UNK0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/55943
Mouse Swissprot No.
O88983
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O88983
Rat Gene Link
https://www.uniprot.org/uniprot/59074
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z2Q7
免疫原
Synthesized peptide derived from human STX8 AA range: 42-92
特异性
This antibody detects endogenous levels of STX8 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
组织表达
Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
细胞定位
Membrane ; Single-pass type IV membrane protein . Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity). .
功能
function:Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.,similarity:Belongs to the syntaxin family.,similarity:Contains 1 t-SNARE coiled-coil homology domain.,subcellular location:Preferentially associated with the early endosome. To lesser extends, also present in late endosome, the plasma membrane and coated pits.,subunit:Forms a SNARE complex with STX7, VTI1B and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, VAMP8 and VTI1B. Interacts with VAMP8.,tissue specificity:Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
