产品名称
NUD10 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/170685
Human Swissprot No.
Q8NFP7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NFP7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/102954
Mouse Swissprot No.
P0C027
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P0C027
免疫原
Synthesized peptide derived from human NUD10 AA range: 92-142
特异性
This antibody detects endogenous levels of NUD10 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015],
组织表达
Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.
功能
catalytic activity:Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.,cofactor:Magnesium or manganese. Manganese may be the true cofactor in vivo.,function:Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyzes the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.,similarity:Belongs to the Nudix hydrolase family. DIPP subfamily.,tissue specificity:Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
