产品名称
CTGE5 Rabbit Polyclonal Antibody
基因名称
CTAGE5 MEA11 MEA6 MGEA11 MGEA6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4253
Human Swissprot No.
O15320
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15320/entry
Mouse Swissprot No.
Q8R311
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R311
免疫原
Synthesized peptide derived from human CTGE5 AA range: 253-303
特异性
This antibody detects endogenous levels of CTGE5 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016],
细胞定位
endoplasmic reticulum membrane,membrane,integral component of membrane,endoplasmic reticulum exit site,
功能
disease:Autoantigen found several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL). Isoform 5A and isoform 5B are recognized by patients' sera with tumor specimen of various origins.,disease:Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.,function:Tumor-associated antigen.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the cTAGE family.,tissue specificity:At the protein level, isoform 5A is expressed only in testis. Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at the protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.,tissue specificity:Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
