产品名称
OSBL8 Rabbit Polyclonal Antibody
基因名称
OSBPL8 KIAA1451 ORP8 OSBP10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/114882
Human Swissprot No.
Q9BZF1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BZF1/entry
免疫原
Synthesized peptide derived from human OSBL8 AA range: 290-340
特异性
This antibody detects endogenous levels of OSBL8 at Human
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
组织表达
Widely expressed (PubMed:11735225). Expressed at higher level in macrophages (PubMed:17991739).
细胞定位
[Isoform 1]: Endoplasmic reticulum membrane ; Single-pass membrane protein . Nucleus membrane . The presence of the N-terminus extension contains an overall negative charge that may explain the weak localization to the cortical endoplasmic reticulum (Probable). .; [Isoform 3]: Endoplasmic reticulum membrane ; Single-pass membrane protein. Localizes to the cortical endoplasmic reticulum at the endoplasmic reticulum-plasma membrane contact sites. .
功能
similarity:Belongs to the OSBP family.,similarity:Contains 1 PH domain.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
