产品名称
ASTL Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/431705
Human Swissprot No.
Q6HA08
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6HA08/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/215095
Mouse Swissprot No.
Q6HA09
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6HA09
免疫原
Synthesized peptide derived from human ASTL AA range: 115-165
特异性
This antibody detects endogenous levels of ASTL at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues.
细胞定位
Cytoplasm . Cell membrane . Cytoplasmic vesicle, secretory vesicle, Cortical granule . Probably exocytosed from cortical granules during post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages. Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS). .
功能
enzyme regulation:Inhibited by wide spectrum metalloproteinase inhibitor batimastat (BB-94). Also inhibited by EDTA.,similarity:Belongs to the peptidase M12A family.,tissue specificity:Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
