产品名称
MICA1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64780
Human Swissprot No.
Q8TDZ2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8TDZ2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/171580
Mouse Swissprot No.
Q8VDP3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VDP3
Rat Gene Link
https://www.uniprot.org/uniprot/294520
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/D3ZBP4
免疫原
Synthesized peptide derived from human MICA1 AA range: 155-205
特异性
This antibody detects endogenous levels of MICA1 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],
组织表达
Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Midbody . Accumulates transiently at the abscission site before abscission occurs. .
功能
cofactor:FAD .,domain:The C-terminal coiled coil part contains the plexin-interacting region.,function:May be a cytoskeletal regulator that connects NEDD9 to intermediate filaments.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 LIM zinc-binding domain.,subunit:Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.,tissue specificity:Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
