产品名称
H2AW Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55506
Human Swissprot No.
Q9P0M6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P0M6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/404634
Mouse Swissprot No.
Q8CCK0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CCK0
免疫原
Synthesized peptide derived from human H2AW AA range: 151-201
特异性
This antibody detects endogenous levels of H2AW at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Oct 2015],
细胞定位
Nucleus . Chromosome . Enriched in inactive X chromosome chromatin (PubMed:11331621, PubMed:11262398) and in senescence-associated heterochromatin (PubMed:15621527). .
功能
function:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.,similarity:Contains 1 histone H2A domain.,similarity:Contains 1 Macro domain.,subcellular location:Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
