产品名称
HDA11 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/79885
Human Swissprot No.
Q96DB2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96DB2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/232232
Mouse Swissprot No.
Q91WA3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91WA3
免疫原
Synthesized peptide derived from human HDA11 AA range: 170-220
特异性
This antibody detects endogenous levels of HDA11 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009],
组织表达
Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
功能
catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,miscellaneous:Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.,sequence caution:Translated as Gln.,similarity:Belongs to the histone deacetylase family.,subcellular location:Predominantly nuclear.,subunit:Interacts with HDAC6.,tissue specificity:Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
