产品名称
LCOR Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84458
Human Swissprot No.
Q96JN0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96JN0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/212391
Mouse Swissprot No.
Q6ZPI3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6ZPI3
免疫原
Synthesized peptide derived from human LCOR AA range: 244-294
特异性
This antibody detects endogenous levels of LCOR at Human/Mouse
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008],
功能
function:May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.,similarity:Contains 1 HTH psq-type DNA-binding domain.,subunit:Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
