产品名称
GPAA1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8733
Human Swissprot No.
O43292
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43292/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14731
Mouse Swissprot No.
Q9WTK3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTK3
免疫原
Synthesized peptide derived from human GPAA1 AA range: 111-161
特异性
This antibody detects endogenous levels of GPAA1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
function:Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.,pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.,sequence caution:Erroneous prediction from an unspliced cDNA.,subunit:Forms a complex with PIGK/GPI8, PIGT, PIGU and PIGS.,tissue specificity:Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
