产品名称
SHOX2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6474
Human Swissprot No.
O60902
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60902/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20429
Mouse Swissprot No.
P70390
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70390
Rat Gene Link
https://www.uniprot.org/uniprot/25546
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O35750
免疫原
Synthesized peptide derived from human SHOX2 AA range: 37-87
特异性
This antibody detects endogenous levels of SHOX2 at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300,FCM 1:100-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009],
组织表达
Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta.
功能
developmental stage:Expressed during cranofacial development as well as in heart.,function:May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.,similarity:Belongs to the paired homeobox family. Bicoid subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 OAR domain.,tissue specificity:Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
