产品名称
FUT1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2523
Human Swissprot No.
P19526
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P19526/entry
Mouse Swissprot No.
O09160
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O09160
Rat Gene Link
https://www.uniprot.org/uniprot/81919
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q10980
免疫原
Synthesized peptide derived from human FUT1 AA range: 150-200
特异性
This antibody detects endogenous levels of FUT1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016],
细胞定位
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Membrane-bound form in trans cisternae of Golgi. .
功能
catalytic activity:GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.,function:Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.,miscellaneous:There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.,online information:Blood group antigen gene mutation database,online information:Fucosyltransferase 1,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,polymorphism:Nonfunctional mutant of FUT1 are the cause of the H-Bombay blood group.,similarity:Belongs to the glycosyltransferase 11 family.,subcellular location:Membrane-bound form in trans cisternae of Golgi.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
