产品名称
GPX2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2877
Human Swissprot No.
P18283
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P18283/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/14776
Mouse Swissprot No.
Q9JHC0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHC0
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P83645
免疫原
Synthesized peptide derived from human GPX2 AA range: 113-163
特异性
This antibody detects endogenous levels of GPX2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016],
组织表达
Mostly in liver and gastrointestinal tract, not found in heart or kidney.
细胞定位
Cytoplasm, cytosol .
功能
catalytic activity:2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.,function:Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.,similarity:Belongs to the glutathione peroxidase family.,subcellular location:Mainly cytoplasmic.,subunit:Homotetramer.,tissue specificity:Mostly in liver and gastrointestinal tract, not found in heart or kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
