产品名称
DEGS2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/123099
Human Swissprot No.
Q6QHC5
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6QHC5/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/70059
Mouse Swissprot No.
Q8R2F2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R2F2
Rat Gene Link
https://www.uniprot.org/uniprot/314438
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q564G3
免疫原
Synthesized peptide derived from human DEGS2 AA range: 92-142
特异性
This antibody detects endogenous levels of DEGS2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008],
组织表达
Highly expressed in skin, intestine and kidney.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
function:Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase.,induction:Up-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after differentiation, detected on day 6 and increases by day 9.,pathway:Membrane lipid metabolism; sphingolipid biosynthesis.,similarity:Belongs to the fatty acid desaturase family. DEGS subfamily.,tissue specificity:Highly expressed in skin, intestine and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
