产品名称
CPSF1 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/29894
Human Swissprot No.
Q10570
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q10570/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/94230
Mouse Swissprot No.
Q9EPU4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EPU4
免疫原
Synthesized peptide derived from human CPSF1 AA range: 564-614
特异性
This antibody detects endogenous levels of CPSF1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008],
组织表达
Widely expressed, with high expression in the retina.
细胞定位
Nucleus, nucleoplasm.
功能
function:Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.,PTM:The N-terminus is blocked.,similarity:Belongs to the CPSF1 family.,subunit:Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
