产品名称
TKNK Rabbit Polyclonal Antibody
基因名称
TAC3 NKNB UNQ585/PRO1155
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6866
Human Swissprot No.
Q9UHF0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UHF0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/21334
Mouse Swissprot No.
P55099
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P55099
Rat Gene Link
https://www.uniprot.org/uniprot/29191
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P08435
免疫原
Synthesized peptide derived from human TKNK AA range: 6-56
特异性
This antibody detects endogenous levels of TKNK at Human/Mouse/Rat
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016],
功能
developmental stage:In pregnancy, the expression of NKB is confined to the outer syncytiotrophoblast of the placenta, significant concentrations of NKB can be detected in plasma as early as week 9, and plasma concentrations of NKB are grossly elevated in pregnancy-induced hypertension and pre-eclampsia.,function:Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.,similarity:Belongs to the tachykinin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
